Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ammonium Glycyrrhizinate (Glycyram) 抑制几种不相关的 DNA/RNA 病毒的细胞病理学和生长。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 100 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 398 | 现货 |
产品描述 | Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses. |
体外活性 | Ammonium glycyrrhizinate (AG) markedly protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also dose-dependently inhibits FeSO(4)-induced reactive oxygen radicals. |
体内活性 | Ammonium glycyrrhizinate down-regulates the TNF-α level and up-regulates IL-10 level and inhibits the cAMP-PDE activity in the lung tissue of mice. Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate increases HDL levels in rats. Ammonium glycyrrhizinate significantly decreases cholesterol, triglyceride, LDL and very VLDL levels in rats. |
别名 | Glycyram, 甘草酸单铵盐, Glycamil, AMGZ |
分子量 | 839.96 |
分子式 | C42H62O16·NH3 |
CAS No. | 1407-03-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 155 mg/mL (184.5 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 5 mg/mL (5.95 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.1905 mL | 5.9527 mL | 11.9053 mL | 29.7633 mL |
5 mM | 0.2381 mL | 1.1905 mL | 2.3811 mL | 5.9527 mL | |
DMSO | 10 mM | 0.1191 mL | 0.5953 mL | 1.1905 mL | 2.9763 mL |
20 mM | 0.0595 mL | 0.2976 mL | 0.5953 mL | 1.4882 mL | |
50 mM | 0.0238 mL | 0.1191 mL | 0.2381 mL | 0.5953 mL | |
100 mM | 0.0119 mL | 0.0595 mL | 0.1191 mL | 0.2976 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ammonium Glycyrrhizinate 1407-03-0 Metabolism Dehydrogenase Glycyram 甘草酸单铵盐 Glycamil AMGZ Inhibitor inhibitor inhibit